Magnesium Is Essential

June 15, 2018 


Magnesium is essential for you to get the benefits of Vitamin D

It’s well known that certain nutrients have cofactors which they rely on for proper utilization and absorption. Vitamin D and Magnesium also falls in same relationship, there is a synergistic link between vitamin D and magnesium too. Specifically, those who fail to get enough magnesium may be unable to properly utilize vitamin D. In essence, magnesium deficiency causes vitamin D to be stored and inactive. Intestinal absorption and metabolism of vitamin D is influenced by magnesium.

Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including:

  • Protein synthesis
  • Muscle and nerve transmission
  • Neuromuscular conduction
  • Signal transduction
  • Blood glucose control
  • Blood pressure regulation

 

Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed. Furthermore, because of chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods, the vast majority of people in modern societies are at risk for magnesium deficiency. Certain individuals will need to be supplemented with magnesium in order to prevent suboptimal magnesium deficiency, especially if trying to obtain an optimal magnesium status to prevent chronic disease.

Causes of magnesium deficiency.

  • Vitamin D excess or deficiency
  • Calcium supplements
  • Alcohol
  • Ageing
  • Caffeine
  • Chronic stress
  • Diabetes
  • Diarrhoea
  • Emotional and/or psychological stress
  • Excessive or prolonged lactation
  • Excessive menstruation
  • Pregnancy

Magnesium: Deficiency signs and symptoms1:

GENERAL Anxiety, lethargy, weakness, agitation, depression, dysmenorrhea, hyperactivity,
headache, irritability, dysacusis, low stress tolerance, loss of appetite, nausea, sleep disorders, impaired athletic performance
MUSCULOSKELETAL Muscle spasm, cramps in the soles of the feet, leg cramps, facial muscles,
masticatory muscles, and calves, carpopedal spasm, back aches, neck pain, urinary spasms, magnesium deficiency tetany.
NERVES/CNS Nervousness, increased sensitivity of NMDA receptors to excitatory
neurotransmitters, migraine, depression, poor memory, seizures, tremor, vertigo.
GASTROINTESTINAL TRACT Constipation
CARDIOVASCULAR Risk of arrhythmias, supraventricular or ventricular arrhythmias, hypertension, coronary spasm,
decreased myocardial pump function, digitalis sensitivity.
ELECTROLYTES Hypokalaemia, hypocalcaemia, retention of sodium.
METABOLISM Dyslipoproteinemia (increased blood triglycerides and cholesterol), decreased glucose tolerance, insulin resistance,
increased risk of metabolic syndrome, disturbances of bone and vitamin D metabolism, resistance to PTH, low circulating levels of PTH,
resistance to vitamin D, low circulating levels of 25(OH)D, recurrence of calcium oxalate calculi.
PREGNANCY Pregnancy complications (e.g., miscarriage, premature labor, eclampsia etc.).
MISCELLANEOUS Asthma, chronic fatigue syndrome, osteoporosis, hypertension, altered glucose homeostasis.

Why Magnesium should be given Vitamin D:

Magnesium is the fourth most abundant mineral in the body after calcium, potassium and sodium. Magnesium activates hundreds of enzymes that are involved in many important biological reactions, including the enzymes that play a role in vitamin D metabolism.

Firstly, the internal process which converts vitamin D into its biologically active form is magnesium-dependent.

Secondly, magnesium acts as a cofactor for the vitamin D-binding protein.

And thirdly, all enzymes that metabolize vitamin D appear to require magnesium to facilitate enzymatic reactions in the liver and kidneys.

Proper intake of magnesium will potentiate the effectiveness of vitamin D in your system, thereby helping preserve bones and muscles and strenghthen immune system. In turn, activated vitamin D increases your body’s ability to absorb magnesium, which is involved in various biochemical reactions.

What is Recommended Dietary intake of Magnesium?

The estimated amount of a nutrient per day, considered necessary for the maintenance of good health. As per current RDA magnesium intake should be 340 mg per day for man and 310 mg per day for woman.

The purpose of this article is to present the biological importance of magnesium in vitamin D metabolism and its therapeutic importance to minimize complications related to vitamin D deficiency. As per our discussion in article, it is essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D.

References:
1. Nutrients 2015, 7, 8199-8226; doi:10.3390/nu7095388
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/pdf/openhrt-2017-000668.pdf